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Image Search Results
Journal: eLife
Article Title: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
doi: 10.7554/elife.54275
Figure Lengend Snippet: Figure 3. Criteria used to classify DT sleep. (A) Representative EEG and EMG traces and EEG power spectral density during NREM and REM sleep for OXMC mice after 4 weeks in the DOX(+) and DOX(-) conditions and for OX mice after 4 weeks in the DOX(-) condition. (B) Representative EEG and EMG traces and EEG power spectral density during cataplexy in OXMC DOX(-) and OX DOX(-) mice. (C) Representative EEG and EMG traces and EEG power spectral density during DT sleep in OXMC DOX(-) mice. DT sleep was characterized by low EMG amplitude with high EEG spectral power in the d (1–5 Hz) and q (6–10 Hz) bandwidths. (D) Relative EEG power during NREM, REM, cataplexy and DT sleep in OXMC DOX(-) mice (n = 6–8) from 0 to 4 weeks DOX(-). The greatest EEG power across all stages was set at 100% for each mouse. Values are presented as mean ± SEM. (E) Relative EEG power in the standard frequency bands (d, q, a and b) for each state. The sum of each band is 100%. Values are presented as mean ± SEM. *p<0.05. Data were Figure 3 continued on next page
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Journal: eLife
Article Title: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
doi: 10.7554/elife.54275
Figure Lengend Snippet: Figure 4. DOX removal from the diet in OXMC mice does not affect relative EEG power distribution or the EMG integral. (A) Relative EEG power in three strains of mice in the DOX(+) condition (before DOX removal) during the dark phase. Upper graphs show relative EEG power at 1 Hz resolution; lower graphs present the standard EEG frequency bands. (B) As in (A) but for the light phase. (C) Relative EEG power of OXMC mice measured during Figure 4 continued on next page
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Journal: eLife
Article Title: Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy
doi: 10.7554/elife.54275
Figure Lengend Snippet: Figure 10. Comparison of EEG spectral power during DT sleep to the transition from NREM to REM sleep. (A) Typical traces of EEG and EMG during the transition from NREM to REM sleep (upper) and during DT sleep (lower). Three epochs during the transition from NREM sleep to REM sleep were analyzed. (B) Comparison of relative EEG power during the transition from NREM to REM sleep in OXMC DOX(-) mice during ablation (0, 3, and 4 weeks DOX(-)).The upper graph shows relative EEG power distribution. The lower bar graph shows the relative EEG power in each spectral band (d, q, a and b). Values are mean ± SEM. Data were analyzed by one-way ANOVA followed by the Bonferroni post hoc test. (C) Comparison of relative EEG power and EMG integral (inset) during DT sleep and the transition from NREM to REM sleep in OXMC DOX(-) mice. Upper graph shows relative EEG power distribution; lower bar graph shows relative EEG power in each band (d, q, a and b). Values are mean ± SEM. Paired t-test. The online version of this article includes the following source data for figure 10:
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Techniques: Comparison